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Scientists extend women’s fertility, reverse ageing in human egg cells

  In a major breakthrough, Israeli scientists claim to have extended women’s fertility by successfully reversing the ageing mechanism in eggs using antiviral drugs.
In humans, egg cells begin to accumulate damage to their genetic material when a woman is relatively young. Often by the time she is in her late-hirties, her eggs have accumulated so much damage to the DNA that they are unable to mature and be fertilised.
Researchers at the Hebrew University of Jerusalem (HU) showed that antiviral drugs could indeed reverse the process in mouse and human egg cells and return to their former youthful selves.
There has also been similar success using genetic manipulation to insert two genes into the mouse egg cell DNA - the implanted genes produce enzymes which prevent the chain of events that leads to the activation of the damaging parts of the DNA.
“Within a decade, I hope we will be able to increase fertility among older women using antiviral drugs,” said Michael Klutstein, head of the Chromatin and Ageing Research Lab in the Faculty of Dental Medicine at the HU.
The findings were published in the journal Ageing Cell.
The team successfully identified one of the ageing processes that prevent the successful maturation of an egg cell.
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