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Scientists extend women’s fertility, reverse ageing in human egg cells

  Researchers have teamed up to modify red blood cells to transport viral agents which can safely trigger the immune system to protect the body against SARS-CoV-2, creating a promising new vehicle for vaccine delivery.
The new method, described in the journal PLOS ONE, is said to be a unique approach to vaccination. Red blood cell membranes are embedded with SARS-CoV-2 spike proteins, which then form virus-like particles.
"We take red blood cells and remove everything from the inside. We then attach spike proteins to their outside to mimic a coronavirus," explained co-author Isabella Passos Gastaldo from McMaster University, Canada.
The particles, shown to activate the immune system and produce antibodies in mice, are completely harmless.
"Current vaccine delivery methods often cause drastic immune system reactions and have short-lived responses," said another researcher. much damage to the DNA that they are unable to mature and be fertilised.
Researchers at the Hebrew University of Jerusalem (HU) showed that antiviral drugs could indeed reverse the process in mouse and human egg cells and return to their former youthful selves.
There has also been similar success using genetic manipulation to insert two genes into the mouse egg cell DNA - the implanted genes produce enzymes which prevent the chain of events that leads to the activation of the damaging parts of the DNA.
“Within a decade, I hope we will be able to increase fertility among older women using antiviral drugs,” said Michael Klutstein, head of the Chromatin and Ageing Research Lab in the Faculty of Dental Medicine at the HU.
The findings were published in the journal Ageing Cell.
The team successfully identified one of the ageing processes that prevent the successful maturation of an egg cell.
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